Colorectal cancer
Colorectal cancer starts in the cell tissues of the colon or the rectum, which form the large intestine, the longest part and the end part, respectively.
Adenocarcinomas account for 90 to 95% of all large bowel cancers, including the large intestine. They originate in the mucosa from a benign growth or polyp (adenoma).
It has been estimated that for the year 2011, 22,200 new colorectal cancer diagnoses would be made in Canada and 8,900 Canadians would die from the disease, 56% men for 44% women. One in 13 Canadian men and one in 16 Canadian women are expected to develop colorectal cancer during their lifetime. Based on recent statistics, one in 28 Canadian men and one in 32 Canadian women will die of it.
Colorectal cancer is the second deadliest type of cancer amongst Canadians, men and women combined. The relative 5-year survival rate for colorectal cancer in Canada is estimated at 63%.
This section is still in construction. Please come back shortly for a more complete description of the disease.
Research projects focused on this topic
- Role of MEK 1/2 signalling in chromosomal instability and colorectal cancer progression
- Dietary risk factors for colorectal cancer
- Functional interactions of the vitamin D receptor with Class III histone deacetylase Sirtuin 1
- Genetic control of susceptibility to colon cancer development
- Role of MEK-ERK1/2 signaling in the initiation, genetic instability and maintenance of colorectal cancer
- Delineating the role of the mismatch repair pathway in suppressing colon carcinogenesis
- Assessing the contribution of spindle assembly checkpoint genes to colorectal neoplasia
- Molecular Characterization of the Role of CSB in Tumorigenesis









