Metastasis
Cancer cells can spread to other parts of the body through the blood and lymph systems; when this occurs, the cancer has metastasized. The property of cancer cells to invade and colonize other tissues is called metastasis.
In most human cancer, it is not the primary tumour that causes the death of the patient, but instead a subsequent tumour that often grows at a different site (secondary, tertiary, etc. tumours).
To obtain the best prognosis, a cancer must be diagnosed at early stages, when the cancer has not metastasized.
If a cancer originated in the lung and has metastasized to the brain, it is still a lung cancer; it remains named from the primary site in the cancer. When cancer cells metastasize and cause secondary tumours, the cells in the metastatic tumour do not have the properties of the cells from the tissue they invade, but are similar to those found in the original organ.
Research projects focused on this topic
- The role of leukocytes and inflammation in enhancing tumour metastasis
- Involvement of IkappaB kinase-epsilon (IKKe) and IL-6 dysregulation in prostate cancer progression
- Akt isoforms in IGF-IR-induced mammary tumour growth and progression
- RET receptor-Interactions with the cadherin-catenin adhesion complex
- Role of nodal in breast cancer metastasis
- The Role of Tissue Factor Following Surgery in the Development of Postoperative Metastatic Disease
- Exploring the Cten-DLC1 signaling axis for cancer intervention
- Functional relationship between EGR-1 and MMP-9 during lymphoma progression
- Tumour-induced osteoclast resistance to bisphosphonate action
- Models for the identification of novel molecular targets and therapeutics for organ specific metastasis of breast cancer
- Characterization of the hypomethylation status of the RUNX1 and RUNX2 genes in advanced ovarian cancer: possible role of RUNX1 and RUNX2 in ovarian cancer progression, invasion/metastasis and chemoresistance
- The Role of PRMT1 Alternatively Spliced Isoform v2 in Breast Cancer Pathogenesis
- Regulation of PAR-6 levels during cell polarity establishment and maintenance
- Mechanisms of anti-angiogenic role of ING4 in human melanoma
- Molecular Characterization of the Pseudopodia of Metastatic Tumor Cells
- Regulation of the pro-invasive properties of neuroblastoma-initiating cells by membrane-type 1 matrix metalloproteinase
- Defining Mechanisms by which CCN3 Promotes the Formation of Osteolytic Bone Metastases
- mTOR inhibition and translation control of pancreatic neuroendocrine tumours
- Identifying novel biomarkers for renal cell carcinoma through quantitative proteomic analysis: Moving into an era of personalized medicine
- Quantitative Analysis of Cytokinesis in situ
- Link between osteolysis and pain during breast cancer metastases to bone









