Half of all patients diagnosed with cancer will eventually succumb to the disease, clearly underscoring the need for development of new, more effective therapeutics.  Gene therapy, the delivery of therapeutic DNA to cells, holds great promise for treatment of cancer, yet all current delivery systems suffer from an inability to effectively target tumour cells.  We have developed new gene delivery vehicles, based on a common cold virus, that can specifically bind to and infect cancer cells in tissue culture.  The goal of our research is to expand upon our initial studies and explore the efficiency of these improved vectors in animal models of cancer.