What makes cancer fatal are metastases, the movement of tumor cells from the site of the primary tumor (i.e. breast) to other organs (i.e. bone, lung). Understanding the process of cell migration is therefore essential in our fight against cancer. Our work shows that the eEF1A2 gene is highly expressed in ~50% of breast and ovarian tumors. It also shows that eEF1A2 increases the rate of cell migration by causing the creation of a cell structure called a filopodia. This suggests that eEF1A2 has some role in metastasis. The overall objective of this project is to understand the molecular mechanism by which eEF1A2 promotes cell migration and filopodia creation. To this end, we propose to understand the role that eEF1A2 has in controlling three other proteins, Cdc42, Akt and PI4K. We hypothesize that by understanding eEF1A2 function, we will identify the molecular mechanisms through which tumour cells metastasize.