Weight loss is commonly seen in patients with different cancer types and provides an important prognostic indicator at all stages of the illness. The liver plays a central role in all aspects of metabolism in patients with cancer, in part as response to signals released by the tumour. Cancer cachexia is a severe form of weight loss that is accompanied by widespread changes in the expression of genes that control liver metabolism. Our research will attempt to identify the proteins that cause these changes in order to better understand how cancer cachexia can be reversed. This would provide important benefits to patients with cancer, as cancer cachexia often leads to rapid progression of the cancer and is frequently associated with severe malaise, fatigue and anorexia.