Prostate cancer is the most frequently diagnosed cancer and a leading cause of cancer death in Canadian men. Advanced prostate cancer, for which treatment remains palliative, is thought to occur as a multi-step process involving growth factors and cytokines. Several inflammatory cytokines have been identified to be involved in carcinogenesis. One of these is the interleukin IL-6 which has a growth-promoting role in prostate cancer and acts as a positive growth factor for most prostate cancer cells in culture. The combination of published results with our own observations suggests that the protein IKKe acts on intracellular mechanisms leading to IL-6 expression in prostate cancer cells and could be involved in the progression of cancer. We will determine in vitro, using cell models, and in vivo, using mouse models, the influence of IKKe expression on three biological properties of metastatic cancer cells: proliferation, cell motility and invasion potential. We will also evaluate IKKe as a prognostic marker for cancer recurrence and the risk of developing metastases in prostate cancer.