Title:   
Associate Professor & Director of the Neurosciences Centre

Institute:
Centre Hospitalier de l'Université de Sherbrooke

Department:  
Physiology & biophysics

Province:
Quebec

Training:  
D.E.A., Pharmacology, Université Nice Sophia-Antipolis, France
PhD, Molecular Biology & Cellular Pharmacology, Molecular & Cellular Pharmacological Institute, UMR 6097, France
Postdoctoral Fellow, Neurosciences, McGill University, Montreal, Quebec, Canada
 
Research interests:
Cancer, Pain, Neurosciences

Recognitions: 
Relief Award in Medical Research, Medical Sciences, Foundation Centre Hospitalier Universitaire de Sherbrooke, 2009
Jean-de-Margerie Award, Best Publication of the Year, University of Sherbrooke, Canada, 2009
   
Career highlights:
Co-director of the Quebec Pain Research Network

Research Projects

Project title:
Role of neurotensin receptor in cancer chronic pain

Funding period:  
2010-2012

Program:
Operating Grant (Basic Research)

Summary:
To have cancer does not necessarily mean living in pain. Nevertheless, to this day, 60 to 90 % of coping patients affected by advanced cancer suffer from moderate to severe pain, independently of their age or sex. In particular, bone metastases are the source of severe pain, escaping current drug therapies such as morphine. By developing an animal model mimicking more closely the pathological pain condition reported by patients suffering from bone cancer, this project aims at developing a new class of non-opioid painkillers targeting the neurotensin receptor family.

CRS publications:

Roussy G., Dansereau M.A., Doré-Savard L., Belleville K., Beaudet N., Richelson E. and Sarret P. (2008). Spinal NTS1 receptors regulate nociceptive signaling in a rat formalin tonic pain model. J. Neurochem. 105(4), 1100-14.

Roussy G., Baudisson S., Dansereau M.A., Ezzoubaa F., Belleville K., Beaudet N., Martinez J., Richelson E. and Sarret P. (2009). Evidence for a role of NTS2 receptors in the modulation of tonic pain sensitivity Molecular Pain. 5, 38.

Doré-Savard L., Otis V., Belleville K., Archambault M., Tremblay L., Beaudoin J.F., Beaudet N., Lecomte R., Lepage M., Gendron L. and Sarret P. (2010). Bbehavioral, medical imaging and histopathological features of a new rat model of bone cancer pain. PLoS ONE 5(10): e13774

Past CRS projects:

2006 Role of the NTS2 receptor in cancer pain