Title:
Professor

Institute:
Institut national de la recherche scientifique (INRS)

Department:  
INRS-Institut Armand-Frappier

Province:
Quebec

Training:  
Postdoctoral Fellow, Department of Pathology, Harvard University, Boston, MA, USA
PhD, Immunology, University of Toronto, Toronto, Ontario, Canada
MSc, Virology, Institut Armand-Frappier, Laval, Quebec, Canada
BSc, Biology, Université du Québec à Montréal, Montreal, Quebec, Canada

Research interests:
matrix metalloproteinases (MMP), metastasis, galectins 

Research Projects

Project title: 
Functional relationship between EGR-1 and MMP-9 during lymphoma progression

Funding period:  
2010-2012

Program:
Operating Grant (Basic Research)

Summary:
Matrix metalloproteinases (MMPs) are a family of enzymes that are a key component in the development of mammalian organisms by providing the space in which cells will be able to multiply. In tumor–bearing subjects, some MMPs are found in higher concentrations, and it has been postulated that they make a nest in which tumors can develop. In this proposal, we propose to pin-point the mechanisms regulating MMP production in cancer. This will pave the way for a targeted therapy that will counteract the tumor enhancing properties of MMPs.

CRS publications:

Bouchard F, Bélanger SD, Biron-Pain K, St-Pierre Y. 2010. Up-regulation of egr-1 gene expression in endothelial cells following interaction with lymphoma cells. Blood Aug 5;116(5):759-66.

Aubé C, Bélanger S, and St-Pierre Y. 2010. Lymphoma cells contribute to the increase of plasma sL-selectins in the serum of lymphoma-bearing mice. Leukemia and Lymphoma Jan;51(1):125-31.

Belanger S, St-Pierre Y. 2005. Role of selectins in triggering, growth, and dissemination of lymphoma: Implication of L-selectin in growth of Thymic lymphoma. Blood Jun 15;105(12):4800-6.

Past CRS projects:

2006 The interplay between adhesion molecules and EGR-1 at the late stages of metastasis
 
2004 The role of selectins in T cell lymphoma
 
2002 Triggering and dissemination of lymphoma in genetically engineered selectin-deficient mice