Research

Past research projects (2008-2010)

Researcher

Research centre

Project name

Focus of research

Benoit Barbeau

Université du Québec à Montréal (UQAM), Quebec

Functional comparisons of the antisene proteins encoded by the various HTLV viruses

Leukemia

Isabelle Bourdeau

Hôtel-Dieu de Montréal, Quebec

Characterization of Wnt/beta-catenin signaling in adrenocortical tumours

Carcinoma

Pascal Chartrand

Université de Montréal, Quebec

E2F-regulated microRNAs and cell cycle progression

Multiple cancers

Jocelyn Côté

University of Ottawa, Ontario

The Contribution of Specific Protein Arginine Methyltransferases and their substrates to Breast Cancer Tumorigenesis

Breast cancer

Michael E. Cox

Jack Bell Research Centre, Vancouver, British Columbia

Characterizing ERG Transformation of Prostatic Epithelial Cells

Prostate cancer

Gerardo Ferbeyre

Université de Montréal, Quebec

CHES1, a forkhead DNA binding protein with tumour suppressor activities

Multiple cancers

Nicolas Gévry

Université de Sherbrooke, Quebec

Role of histone H3K27 demethylase JMJD3 in estrogen-dependant transcription and breast cancer

Breast cancer

Matthias Götte

McGill University, Montreal, Quebec

Interaction between the polymerase of the hepatitis C virus and different classes of inhibitors

Liver cancer

Douglas Gray

Ottawa Health Research Institute, Ontario

Ubiquitin pools as a potential therapeutic target in lung cancer

Lung cancer

Margaret Hough

Sunnybrook Research Institute, Toronto, Ontario

HOX11 Transcriptional Regulation of Target Genes in T-ALL

Leukemia

Perry L. Howard

University of Victoria, British Columbia

A Small Molecule Approach to Rewiring Erb2 Signalling in Breast Cancer

Breast cancer

Meredith Irwin

The Hospital for Sick Children, Toronto, Ontario

Role of p63 and SATB2 in chemoresistance in HNSCC (head and neck squamous cell carcinoma)

Carcinoma

Xiaoyan Jiang

British Columbia Cancer Agency, Vancouver, British Columbia

Molecular and functional characterization of an AHI-1-BCR-ABL interaction complex in chronic myeloid leukemia

Leukemia

Kenneth Kao

Memorial University of Newfoundland, St. John's, Newfoundland

Regulation of Ribosome Biogenesis by Pygopus in Epithelial Ovarian Cancer

Ovarian cancer

Svetlana Komarova

McGill University, Montreal, Quebec

Tumour-induced osteoclast resistance to bisphosphonate action

Breast cancer, Metastasis

Michel Lebel

Centre de recherche du CHUL (CHUQ), Quebec, Quebec

Identification of protein partners required for YB-1 to confer chemoresistance in breast tumors

Breast cancer, Chemotherapy

David LeBrun

Queen's University, Kingston, Ontario

Developing a B-cell model for leukemia induction by E2A-PBX1

Leukemia, Children and young adult cancers

Jonathan M. Lee

University of Ottawa, Ontario

Control of filopodia production by elongation factor eEF1A2

Metastasis

David Litchfield

University of Western Ontario, London, Ontario

Rational design of novel molecular-targeted inhibitors of cancer cell proliferation.

Multiple cancers, Targeted chemotherapy

Sylvain Meloche

Université de Montréal, Quebec

Role of MEK 1/2 signalling in chromosomal instability and colorectal cancer progression

Colorectal cancer

Anne-Marie Mes-Masson

Hopital Notre-Dame du CHUM, Montreal, Quebec

Involvement of IkappaB kinase-epsilon (IKKe) and IL-6 dysregulation in prostate cancer progression

Prostate cancer, Metastasis

Roger Moorehead

University of Guelph, Ontario

Akt isoforms in IGF-IR-induced mammary tumour growth and progression

Breast cancer, Metastasis

William J. Muller

McGill University Health Centre, Montreal, Quebec

Role of the tumour suppressor PTEN (Phosphatase and Tensin homolog deleted on chromosome Ten) in ErbB-2 induced mammary tumorigenesis

Breast cancer

Lois Mulligan

Queen's University, Kingston, Ontario

RET receptor-Interactions with the Cadherin-Catenin Adhesion Complex

Metastasis

Torsten Nielsen

Vancouver Hospital & Health Sciences Centre, British Columbia

CSF1 pathway inhibitors in primary xenograft models of soft tissue tumors

Sarcoma, Targeted chemotherapy

Robin Parks

Ottawa Health Research Institute, Ontario

Characterization of oncolytic adenovirus vectors designed to specifically infect cancer cells

Gene therapy

Alain Piché

Université de Sherbrooke, Quebec

Identifying signal transduction pathways regulated by malignant ascites

Ovarian cancer

Lisa Porter

University of Windsor, Ontario

Role of Spy1 in Cellular Senescence

Multiple cancers

Isabelle Royal

Hôpital Notre-Dame du CHUM, Montreal, Quebec

Regulation of VEGF-dependent signaling and angiogenic responses by the DEP-1 protein tyrosine phosphatase

Multiple cancers, Targeted chemotherapy

Martin Simard

Hôtel-Dieu de Québec, Quebec

Extensive study of the RNA interference pathway: a new hope to battle against Cancer

Multiple cancers

Andrew Swan

University of Windsor, Ontario

Identification of Cks-SCFSkp2 Substrates in Drosophila

Multiple cancers

Fumio Takei

British Columbia Cancer Agency, Vancouver, British Columbia

Anti-tumour immune responses mediated by NKDC

Immunotherapy

Patricia Tonin

Montreal General Hospital, Quebec

Deletion analysis of BRCA1 and BRCA2 loci in high risk breast and/or ovarian cancer families of French Canadian descent

Breast cancer, Ovarian cancer

Eva Turley

University of Western Ontario, London, Ontario

Mechanisms for the oncogenic effects of breast cancer susceptibility oncogene, RHAMM/HMMR.

Breast cancer

Luc Vallieres

Centre hospitalier de l'Université Laval (CHUL), Quebec, Quebec

Interactions between brain tumour cells and the immune system

Brain & Nervous system tumours, Immunotherapy

Peter Whyte

McMaster University, Hamilton, Ontario

Regulation of E2F4 by Phosphorylation

Multiple cancers

Nadine Wiper-Bergeron

University of Ottawa, Ontario

The Inhibition of MyoD Expression and skeletal Muscle Differentiation by C/EBPbeta in Cancer Cachexia

Multiple cancers